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简介

        别亚男，博士，广东药科大学基础医学院病理与病理生理系讲师，中共党员。承担病理学教学课程，培养硕士研究生5名，承担课题4项，发表科研论文十余篇。

教育背景及工作经历

2016-09 至 2019-06, 南方医科大学, 动物学, 博士

2010-09 至 2013-06, 广东医科大学, 妇产科, 硕士

2005-09 至 2010-06, 湖北科技学院, 临床医学, 学士

2019-07 至 今, 广东药科大学, 基础医学院, 讲师

学术兼职

中国实验动物学会会员

承担科研课题

1.   广东省基础与应用基础研究基金委员会, 区域联合基金-青年基金项目, 2022A1515110078, 间充质干细胞外泌体通过抑制Ly6CHi单核细胞分化促进弥漫性肺出血肺泡修复及其机制研究, 2022-10 至 2025-09, 10 万元, 在研, 主持

2.  广州市科学技术局, 基础研究计划, 202201010358, 基于自噬探索骨髓间充质干细胞外泌体加载雷帕霉素修复骨关节炎的作用及机制, 2022-04 至 2024-03, 5万元, 已结题, 主持

3.  广东省卫生健康委员会, 广东省医学科学技术研究基金项目, 20191116171711785, 基因编辑人脐带间充质干细胞的抗衰老机制探讨及安全性评价研究, 2020-07 至 2022-11, 0.5万元, 已结题, 主持

4.  广东省科学技术厅, 广东省企业科技特派员项目, GDKTP2020041900, 间充质干细胞修复骨关节炎软骨缺损的安全性及有效性研究, 2020-09 至 2021-09, 3.2万元, 已结题, 主持

科研论文

1. Ya-Nan Bie; Peng Gu; Yu-ting Chen; Xiao-xu Zhou; Yu-guang Tian; Qin Yang; Hai-yan Li; Xia Lin; Yan-hong Guan; Tao-yan Lin; Xun Lu; Hong-fen Shen; Ting-xiao Fang; Yu-min Liu; Dong Xiao; Wei-Wang Gu ; TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway, Journal of Translational Medicine, 2019, 17(1): 72

2. Peng Gu; Qin Yang; Bangzhu Chen; Ya-nan Bie; Wen Liu,; Yuguang Tian; Hongquan Luo; Tao Xu; Chunjin Liang; Xing Ye; Yan Liu; Xiangwu Tang; Weiwang Gu ; Genetically blocking HPD via CRISPR-Cas9 protects against lethal liver injury in a pig model of tyrosinemia type I, Molecular Therapy: Methods & Clinical Development, 2021, 21(21): 530-547

3. Yanan Bie; Qianqing Chen; Jiahuan Xu; Baofang Ou; Boyu Chen; Yajin Guan; Shuilin Xie ; Human umbilical-cord-derived mesenchymal stem cells in combination with rapamycin reduce cartilage degradation via inhibition of the AKT/mTOR signaling pathway, Immunopharmacology and Immunotoxicology, 2023, 45(5): 549-557

4. Yajin Guan; Qianqing Chen; Jiahuan Xu; Boyu Chen; Baofang Ou; Tianping Liu; Shuiling Xie; Yanan Bie ; The anti‐inflammatory effects of mesenchymal stem cells attenuate diffuse pulmonary hemorrhage, Biotechnology Journal, 2023, 19(1)

5. Yajin Guan; Tianping Liu; Fei Xu; Shuilin Xie; Weiwang Gu; Yanan Bie ; Integration of 16S rRNA gene sequencing and LC/MS-based metabolomic analysis of early biomarkers of acute ischaemic stroke in Tibetan miniature pigs, Journal of Microbiological Methods, 2023, 215: 106846

6. 徐菲,刘天平,关雅今,等.基于非靶向代谢组学的缺血性脑卒中生物标志物的分析[J/OL].色谱,1-9[2024-11-21].http://kns.cnki.net/kcms/detail/21.1185.O6.20241105.1011.002.html.

7. 欧宝芳,别亚男,陈千晴,陈柏羽,许佳欢,谢水林,吴少瑜,改良后Hulth 法和II型胶原酶注射法建立兔膝骨关节炎模型的比较研究. 中国比较医学杂志究[J], 2022, 32(2): 29-37.

8. 许佳欢，别亚男，陈千晴，陈柏羽，欧宝芳，谢水林，吴少瑜.两种造模方法建立小鼠先兆子痫模型比较研究[J/OL].中国比较医学杂志.[J], 2023, 33(1): 00-00.

9. 陈千晴，别亚男，陈柏羽，等. 人脐带间充质干细胞治疗小鼠急性肺损伤的安全性及有效性研究 [J]. 中国比较医学杂志， 2022，32( 5) : 77-84.

10. Gao M, Lin Y, Liu X, Zhao Z, Zhu Z, Zhang H, Ban Y, Bie Y, He X, Sun X and Zhang S (2021) TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma. Front. Cell Dev. Biol. 9:654407.

11. Liu, Y. M., Liu, W., Jia, J. S., Chen, B. Z., Chen, H. W., Liu, Y., Bie, Y. N., Gu, P., Sun, Y., Xiao, D., & Gu, W. W. (2018). Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice. Journal of translational medicine, 16(1), 141.

12. Xiao Z, Yao S, Wang Z-m, Zhu D-m, Bie Y-n, Zhang S-z and Chen W-l (2021) Multiparametric MRI Features Predict the SYP Gene Expression in Low-Grade Glioma Patients: A Machine Learning-Based Radiomics Analysis. Front. Oncol. 11:663451. doi: 10.3389/fonc.2021.663451