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简介

        杨军，博士，副研究员，广东药科大学基础医学院病原生物学与免疫系教师， 广东药科大学强药青年学者。从事耐药菌持留机制研究，聚焦临床中的优势耐药基因-病原菌组合，利用分子生物学、遗传学和生物化学等手段，探究耐药基因与宿主菌的互作机制以及优势耐药质粒的生物学特性，包括质粒的复制、转移和适应性调控机制等。近年来，在Nucleic Acids Research, mBio, Trends in Microbiology, Lancet Infect Dis， Zoological Research, mSphere, Microbiol Spectr等国际期刊发表论文19篇。主持国家自然基金、十四五重点研发计划子课题、博士后面上基金，参与国家自然基金重点项目和专项项目等。

教育背景及工作经历

2023.12-至今    广东药科大学 基础医学院   副研究员

2017.09-2023.09 华南农业大学兽医学院    博士后

2011.09-2017.07 华南农业大学生命科学学院 生物化学与分子生物学  博士

2007.09-2011.07    山西农业大学动物科技学院   生物科学（动物方向）  本科

承担科研课题

（1） 国家自然基金青年科学基金，FinO/ProQ 家族蛋白调控mcr-1 阳性IncI2 型质粒适应性的机制研究， 31902322， 2020.01-2022.12， 24万，主持

（2） 科技部“十四五”国家重点研发计划，2022YFC2303904，食源性病原菌交叉耐药基因传播机制及阻断技术子课题， 2022.12-2025.12，60万，主持

（3） 博士后面上基金，C21051，大肠杆菌H-NS调控黏菌素耐药基因mcr-1适应性的机制研究， 2021.6，8万，主持

（4） 国家自然基金重点项目，黏菌素耐药质粒与其宿主菌的适应性进化机制，31830099， 2019.01-2023.12，287万，参加

（5） 国家自然基金专项项目，重要耐药菌/耐药基因在“动物-环境-人群”链条中的传播机制和风险研究-优势耐药克隆和多耐药可移动元件的形成及传播机制，32141002，280万，参加 

科研论文

(1) Jun Yang; Hai-Hong Wang, Yaoyao Lu, Ling-Xian Yi, Yinyue Deng, Luchao Lv, Vincent Burrus, Jian-Hua Liu*, A ProQ/FinO family protein involved in plasmid copy number control favours fitness of bacteria carrying mcr-1-bearing IncI2 plasmids. Nucleic Acids Research. 2021 Apr 19;49(7):3981-3996 IF₂₀₂₃=16.6

(2) Jun Yang#, Renjie Wu#, Qiang Xia#, Jingjing Yu, Ling-Xian Yi, Ying Huang, Meixin Deng, Wan-Yun He, Yuman Bai, Luchao Lv, Vincent Burrus, Chengzhen Wang, Jian-Hua Liu*, The evolution of infectious transmission promotes the persistence of mcr-1 plasmids. mBio. 2023 Jun 14. IF₂₀₂₃ = 5.1

(3) Cheng-Zhen Wang, Xun Gao, Xin-Hong Liang, Lu-Chao Lv, Li-Tao Lu, Chao Yue, Xiao-Xiao Cui, Ke-Er Yang, Duo Lu, Jian-Hua Liu*, Jun Yang*, Pseudomonas Acts as a Reservoir of Novel Tigecycline Resistance Efflux Pump tmexC6D6-toprJ1b and tmexCD-toprJ Variants. Microbiol Spectr. 2023, Apr 17; e0076723. IF₂₀₂₃ =3.7

(4) Yi-Yun Liu #, Xiao-Qing Zhu #, Sue C Nang #, Haoliang Xun, Luchao Lv, Jun Yang*, Jian-Hua Liu*, Greater Invasion and Persistence of mcr-1-Bearing Plasmids in Escherichia coli than in Klebsiella pneumoniae, Microbiol Spectr. 2023 Mar 28;11(2):e0322322. IF₂₀₂₃ =3.7

(5) Wan-Yun He#, Xing-Xing Zhang#, Guo-Long Gao, Ming-Yi Gao, Fa-Gang Zhong, Lu-Chao Lv, Zhong-Peng Cai, Xing-Feng Si, Jun Yang*, Jian-Hua Liu*，Clonal spread of Escherichia coli O101:H9-ST10 and O101:H9-ST167 strains carrying fosA3 and bla_CTX-M-14 among diarrheal calves in a Chinese farm, with Australian Chroicocephalus as the possible origin of E.coli O101:H9-ST10, Zoological Research, 2021, 42(4): 461-468. IF₂₀₂₃ =4.0

(6) Jun Yang, Haiming Cai, Jie Liu, Min Zeng, Jiawei Chen, Qingmei Cheng, Linghua Zhang*, Controlling AOX1 promoter strength in Pichia pastoris by manipulating poly (dA:dT) tracts. Sci Rep, 2018 Jan 23;8(1):1401.  IF₂₀₂₃ =3.8

(7) Jun Yang, Zhipeng Lu, Jiawei Chen, Pinpin Chu, Qingmei Cheng, Jie Liu, Feiping Ming, Chaoyuan Huang, Anji Xiao, Linghua Zhang*, Effect of cooperation of chaperones and gene dosage on the expression of porcine PGLYRP-1 in Pichia pastoris. Applied Microbiology and Biotechnology, 2016, 100(12):5453-5465 IF₂₀₂₃ =3.9

(8) Jun Yang, Miaopeng Ma, Shuiqing Zhang, Huazhou Li, Zhenggu Jiang, Guangjun Cao, Ding Cao, Xingfu Wang, Linghua Zhang*, Innate defense regulator peptide synergizes with CpG ODN for enhanced innate intestinal immune response in neonate piglets. International Immunopharmacology , 2012,12(2):415-424  IF₂₀₂₃ =4.8

(9) Chengzhen Wang, Jun Yang, Zeling Xu, Luchao Lv, Sheng Chen, Mei Hong, Jian-Hua Liu*, Promoter regulatory mode evolution enhances the high multidrug resistance of tmexCD1-toprJ1. mBio. 2024 May 8;15(5):e0021824 IF=5.1

(10) Jian-Hua Liu*, Yi-Yun Liu, Ying-Bo Shen, Jun Yang, Timothy R Walsh, Yang Wang*, Jianzhong Shen*, Plasmid-mediated colistin-resistance genes: mcr. Trends in Microbiology. 2024 Apr;32(4):365-378. IF=14.0

(9) Yi-Yun Liu, Qiaoli Zhou, Wanyun He, Qingqing Lin, Jun Yang, Jian-Hua Liu*, mcr-1 and plasmid prevalence in Escherichia coli from livestock, Lancet Infect Dis, 2020 Oct;20(10):1126  IF₂₀₂₃=36.4

(10) Lingxian Yi #, Romain Durand #, Frédéric Grenier, Jun Yang, Kaiyang Yu, Vincent Burrus, Jian-Hua Liu*, PixR, a Novel Activator of Conjugative Transfer of IncX4 Resistance Plasmids, Mitigates the Fitness Cost of mcr-1 Carriage in Escherichia coli, mBio, 2022 Feb 22;13(1):e0320921. IF₂₀₂₃= 5.1

(11) Renjie Wu #, Luchao Lv #, Chengzhen Wang, Guolong Gao, Kaiyang Yu, Zhongpeng Cai, Yiyun Liu, Jun Yang, Jian-Hua Liu*, IS 26-Mediated Formation of a Hybrid Plasmid Carrying mcr-1.1 Infect Drug Resist. 2022 Dec 9;15:7227-7234. IF₂₀₂₃ =2.9

(12) Cheng-Zhen Wang, Xun Gao, Lu-Chao Lv, Zhong-Peng Cai, Jun Yang, Jian-Hua Liu*, Novel tigecycline resistance gene cluster tnfxB3-tmexCD3-toprJ1b in Proteus spp. and Pseudomonas aeruginosa, co-existing with tet(X6) on an SXT/R391 integrative and conjugative element, J Antimicrob Chemother. 2021 Nov 12;76(12):3159-3167 IF₂₀₂₃ =3.9

(13) Cheng-Zhen Wang #, Xun Gao #, Qi-Wen Yang #, Lu-Chao Lv, Miao Wan, Jun Yang, Zhong-Peng Cai, Jian-Hua Liu*, A Novel Transferable Resistance-Nodulation-Division Pump Gene Cluster, tmexCD2-toprJ2, Confers Tigecycline Resistance in Raoultella ornithinolytica，Antimicrob Agents Chemother, 2021 Mar 18;65(4):e02229-20. IF₂₀₂₃=3.9

(14) Yu-Ping Cao# , Qing-Qing Lin# , Wan-Yun He, Jing Wang , Meng-Ying Yi , Lu-Chao Lv , Jun Yang, Jian-Hua Liu*, Jian-Ying Guo*, Co-selection may explain the unexpectedly high prevalence of plasmid-mediated colistin resistance gene mcr-1 in a Chinese broiler farm，Zoological Research, 2020 Sep 18;41(5):569-575. IF₂₀₂₃ =4.0

(15) Luchao Lv # , Xiuyu Huang # , Jing Wang, Ying Huang, Xun Gao, Yiyun Liu, Qiaoli Zhou, Qianhui Zhang, Jun Yang, Jian-Ying Guo, Jian-Hua Liu*，Multiple Plasmid Vectors Mediate the Spread of fosA3 in Extended-Spectrum-β-Lactamase-Producing Enterobacterales Isolates from Retail Vegetables in China, mSphere, 2020 Jul 15;5(4):e00507-20. IF₂₀₂₃ =3.7

(16) Luchao Lv #, Miao Wan #, Chengzhen Wang #, Xun Gao #, Qiwen Yang #, Sally R Partridge, Yang Wang, Zhiyong Zong, Yohei Doi, Jianzhong Shen, Peiyao Jia, Qianhua Song, Qianhui Zhang, Jun Yang, Xianhui Huang, Minggui Wang, Jian-Hua Liu, Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in Klebsiella pneumoniae, mBio. 2020 Mar 3;11(2): e02930-19.一区

(17) Zulqarnain Baloch #, Luchao Lv #, Lingxian Yi, Miao Wan, Bilal Aslam, Jun Yang, Jian-Hua Liu, Emergence of Almost Identical F36: A-: B32 Plasmids Carrying bla_NDM-5 and qepA in Escherichia coli from Both Pakistan and Canada, Infect Drug Resist. 2019 Dec 30; 12:3981-3985. IF₂₀₂₃ =2.9

(18) Luchao Lv, Zhenling Zeng, Qianhua Song, Yuping Cao, Jing Wang, Wei Li, Qiaoling Wen, Qianhui Zhang, Miao Wan, Jun Yang, Jian-Hua Liu, Emergence of XDR Escherichia coli carrying both bla_NDM and mcr-1 genes in chickens at slaughter and the characterization of two novel bla_NDM-bearing plasmids, J Antimicrob Chemother. 2018 Aug 1;73(8):2261-2263. IF₂₀₂₃ =3.9

(19) Renjie Wu, Ling-Xian Yi, Lin-Feng Yu, Jing Wang, Yiyun Liu, Xiaojie Chen, Luchao Lv, Jun Yang, Jian-Hua Liu, Fitness Advantage of mcr-1-Bearing IncI2 and IncX4 Plasmids in Vitro, Front Microbiol. 2018 Feb 27; 9:331. IF₂₀₂₃ =4.0