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姓名:刘涛 副研究员,工学博士,硕士生导师
主要科研方向 生物活性药物的制备、评价与工程技术研究;AI+生物医药
联系方式 通讯地址:广州市番禺区大学城外环东路280号基础医学院B311 邮编:510006,电话:020-39352552; 邮箱:liutao@gdpu.edu.cn |
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个人简介:
刘涛,工学博士,副研究员,硕士研究生导师。2010年毕业于中国科学院过程工程研究所,获生物化工专业博士学位;2012至2014年在南方医科大学基础医学学科从事博士后研究;现为基础医学院-广东省生物活性药物研究重点实验室教师。主要从事生物活性药物的制备、评价与工程技术研究,以及人工智能赋能蛋白药物的创新设计和应用。主持国家自然科学基金、广东省科技计划、广州市科技计划重点项目、广东省普通高校重点科研项目、广州市博士后科研基金及医院/企业合作开发等课题,指导本科生获2023、2024年度大学生创新创业项目国家级立项。发表SCI/EI收录学术论文40余篇;授权发明专利5项,其中1项已实现成果转化;两项研究成果入选《2022中国化妆品科研成果蓝皮书》。入选高等学校“千百十人才培养工程”校级培养对象,作为主要完成人获2021年度广东省自然科学奖二等奖,指导本科生在2023年“共赋未来创益大会”全国赛中获得二等奖。
近年发表科研论文:
1. T. Liu, H. Huang, H. Yin*. Interleukin-33 at the maternal-fetal interface: From immune tolerance to obstetric syndromes. Journal of Reproductive Immunology, 2026, 174: 104855.
2. Y. Li#, J. Liang#, H. Yin*, T. Liu*. Engineering the holobiont: Synthetic biology strategies for reversing bioenergetic collapse in radiation enteritis. AIMS Microbiology, 2026, 12(1): 63-91.
3. R. Zhong, H. Huang, J. Liang, W. Lai, Y. Tan, W. Liu, B. Yuan, Z. He, Y. Tang, T. Liu*, H. Yin*. IGF-1 ameliorates the blood brain barrier disruption induced by the neonatal hypoxia-ischemia. International Immunopharmacology, 2026, 173: 116323.
4. T. Liu, C. Wang, H. Zhou, W. Luo*. Metal-Organic Frameworks as Synergistic Scaffolds in Biomass Fermentation: Evolution from Passive Adsorption to Active Catalysis. Fermentation, 2026, 12(1): 9.
5. T. Liu, M. He, R. Shi, H. Yin*, W. Luo*. Biofuel-Pharmaceutical Co-Production in Integrated Biorefineries: Strategies, Challenges, and Sustainability. Fermentation, 2025, 11(6): 312.
6. Y. Du#, T. Liu#, H.-L. Li#, Q. Luo#, X.-Y. Guo, J.-Y. Wang, X.-R. Wang, Y.-M. Zhou, Y.-W. Pan, L.-C. Yu, H.-M. Tan, K.-S. Hu, S.-S. Tang*. Innovative Glucagon-like Peptide 1 Receptor Agonists: Exploring the Therapeutic Potential of Specific Modified Monomer, Dimer, and Tetramer in Type 2 Diabetes Treatment. Bioconjugate Chemistry, 2025, 36: 1753-1766.
7. T. Liu*, X. Chen*. Bioactive Compounds from Natural Sources: Discovery, Evaluation, and Applications. Molecules, 2024, 29(13): 3209.
8. J. Tian, J. Zhu, Q. Fan, X. Luo, Q. Nie, J. Yu, X. Wu, Y. Tang, T. Liu*, H. Yin*. Interleukin-33 improves the neurogenesis of neural stem cells in perinatal brain after hypoxia–ischemia. International Immunopharmacology, 2023, 123: 110778.
9. T. Liu, Z. Peng, W. Lai, Y. Shao, Q. Gao, M. He, W. Zhou, L. Guo, J. Kang, X. Jin, H. Yin*. The efficient synthesis and anti-fatigue activity evaluation of macamides: The unique bioactive compounds in maca. Molecules, 2023, 28(9): 3943.
10. Q. Dong, J. Tian, W. Zheng, Q. Fan, X. Wu, Y. Tang, T. Liu*, H. Yin*. Interleukin-33 protects mice against hindlimb ischemic injury by enhancing endothelial angiogenesis. International Immunopharmacology, 2022, 109: 108850.
11. L. Guo, Q. Gao, J. Zhu, X. Jin, H. Yin*, T. Liu*. A Docosahexaenoic Acid derivative (N-Benzyl docosahexaenamide) as a potential therapeutic candidate for treatment of ovarian injury in the mouse model. Molecules, 2022, 27(9): 2754.
12. E. Ge, R. Zha, Q. Gao, L. Guo, B. Wang, Q. Lin, G. Zhang, W. Xie, H. Yin, T. Liu*. Preventive effect of swim bladder hydrolysates on cyclophosphamide-induced ovarian injury in mice. Journal of Obstetrics and Gynaecology Research, 2022, 48(2): 420-430.
13. M. Jiao, Q. Dong, Y. Zhang, M. Lin, W. Zhou, T. Liu*, B. Yuan, H. Yin*. Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury. Molecules, 2021, 26(11): 3108.
14. M. Tian#, L. Yang#, Z. Wang, P. Lv*, J. Fu, C. Miao, M. Li, T. Liu*, W. Luo*. Improved methanol tolerance of Rhizomucor miehei lipase based on N glycosylation within the α-helix region and its application in biodiesel production. Biotechnology for Biofuels, 2021, 14(1): 237.
15. R. Zha#, E. Ge#, L. Guo, Q. Gao, Q. Lin, W. Zhou, X. Jin, W. Xie, H. Yin*, T. Liu*. A newly identified polyunsaturated macamide alleviates dextran sulfate sodium-induced colitis in mice. Fitoterapia, 2021, 152: 104916.
授权发明专利:
1. 苄胺化ω-3不饱和脂肪酸的制备方法及其应用. 尹辉, 刘涛, 周婉, 陈丽英, 查睿. ZL 2020100508349.
2. 玛咖酰胺类化合物或其盐在制备预防或治疗肝纤维化疾病药物的应用. 谢伟全, 刘涛, 涂剑, 张素君, 尹辉, 周芊芊, 李子涵. ZL 201910076194.
3. 一种虾青素-胶原蛋白耦合物及其制备方法和应用. 刘涛, 李芸, 周婉, 尹辉, 戴良成, 金小宝. ZL2018104948641.
4. 一种提取玛咖酰胺类化合物的方法. 刘涛, 邵炎, 李芸, 尹辉, 金小宝, 朱家勇. ZL2016102703852.